AOA-OMED Research Posters 2024-OMED24-POSTERS

Video Transcription

Video Summary

Alfredo Pallerina from the West Virginia School of Osteopathic Medicine presents his project on using glutaminase inhibitors, specifically C968 and its analog 15, for treating triple-negative breast cancer and related pain. Analog 15 demonstrated better anticancer and antipain properties than C968, particularly inhibiting brain metastasis cells. While C968 increased chemotherapy-induced pain (CIPN) in both sexes, analog 15 only elevated it in males. Preliminary studies suggest analog 15’s enhanced efficacy is linked to better inhibition of crucial cancer and pain signaling pathways, potentially offering new treatment options for cancer and pain management. Further research is planned.

Keywords

glutaminase inhibitors

triple-negative breast cancer

analog 15

brain metastasis

pain management