AOA - OMED Research Posters 2024-OMED24-POSTERS

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Video Summary

Patrick Keefe, a second-year medical student, presents a study on the LRRK2 gene mutation in Parkinson's disease, focusing on neuromuscular junctions. The study hypothesizes that changes in neuromuscular junctions, particularly nicotinic acetylcholine receptor stability, may precede Parkinson's symptoms. The research involved LRRK2 transgenic mice, assessing muscles involved in respiration and limbs. Findings showed significant reductions in receptor density and motor performance decline. Additionally, observations included increased myonuclei per area and muscle cell stress indications. The study concludes that LRRK2 mutations impact neuromuscular junction integrity with potential clinical relevance.

Keywords

LRRK2 gene mutation

Parkinson's disease

neuromuscular junctions

nicotinic acetylcholine receptor

transgenic mice