AOA-OMED Research Posters 2024-OMED24-POSTERS

Video Transcription

Video Summary

Christopher Detroya presents a study on cell signaling in sensory neurons, addressing the opioid epidemic by exploring new analgesics. The research focuses on mitochondrial uncoupling drugs, like DNP and BAM-15, which show promise in rodents for treating pain without opioids' adverse effects. The study examines the presence of the novel kinase MUOC1 in sensory neurons, using rodent and human cell lines. Positive labeling of MUOC1 in human-derived cells suggests their potential role in pain pathways, aligning with the AMPK family. Limitations include antibody specificity, but the findings highlight the importance of human cell lines in developing non-addictive analgesics.

Keywords

cell signaling

mitochondrial uncoupling

non-addictive analgesics

opioid epidemic

sensory neurons