AOA-OMED Research Posters 2024-OMED24-POSTERS

Video Transcription

Video Summary

Isabella Church, a second-year osteopathic medical student, presented her research on the role of AMPK subunits in doxorubicin-induced cardiotoxicity. The study focused on AMPK beta-1 and beta-2 in regulating autophagy and cardiomyocyte death. Results indicated that AMPK beta-1 knockdown increased autophagy and doxorubicin toxicity, contrasting the prevailing belief that AMPK is cardioprotective. The findings suggest unique roles for AMPK subunits in autophagy and highlight potential protective strategies against doxorubicin's cardiotoxic effects, aiming to balance cancer treatment efficacy with reduced heart damage.

Keywords

AMPK subunits

doxorubicin cardiotoxicity

autophagy

cardiomyocyte death

cancer treatment strategies