AOA-OMED Research Posters 2024-OMED24-POSTERS

Video Transcription

Video Summary

Matthew Cerrone and Ben Caruso, second-year medical students, presented a study on chronic kidney disease (CKD) and its relation to cardiovascular health. CKD increases cardiovascular risks due to dyslipidemia. Using a mouse model induced with adenine, they found a paradoxical reduction in triglycerides when switched from a Western diet. Post-adenine cessation, triglycerides rebounded, but elevated urine output persisted, indicating irreversible renal damage. The study suggests adenine impacts triglyceride synthesis and CKD-linked cardiovascular progression. Future studies will explore CKD biomarkers and continue using this model to understand vascular calcification and disease in CKD patients.

Keywords

chronic kidney disease

cardiovascular health

dyslipidemia

adenine model

triglycerides