AOA-OMED Research Posters 2024-OMED24-POSTERS

Video Transcription

Video Summary

Depora Leavitt and Eugene Tano present a study on factors affecting vascular calcification and aortic stiffness using an animal model of atherosclerosis. They examine TNAP's role, liver-specific TNAP expression, sex-related differences in calcification, and the effect on aortic stiffness. Results show no significant difference in aortic root calcification due to sex or TNAP haploinsufficiency. Notably, females show higher ALP levels, and reduced TNAP leads to a 30% decline in plasma ALP, but no correlation between ALP and calcification. Findings suggest further research, including full liver TNAP knockout comparisons, to better understand this field.

Keywords

vascular calcification

aortic stiffness

TNAP expression

sex differences

atherosclerosis