AOA-OMED Research Posters 2024-OMED24-POSTERS

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Video Summary

Nicholas Basil and Zachary Mendola studied the effects of intranasal gentamicin, an aminoglycoside antibiotic, on neuron morphology in the vestibular nuclei, which are crucial for balance and spatial orientation. Despite existing research on gentamicin's side effects, this study focuses on its impact via the intranasal route, particularly its ototoxicity. In rat models, researchers observed significant morphological and behavioral changes in neurons within the vestibular nuclei. Their findings suggest that gentamicin administration can lead to noticeable alterations in neuron size and shape, reinforcing known ototoxic effects on the vestibular system.

Keywords

intranasal gentamicin

vestibular nuclei

ototoxicity

neuron morphology

rat models