AOA-OMED Research Posters 2024-OMED24-POSTERS

Video Transcription

Video Summary

Student Dr. Belucci from Toro University, California, discusses a project exploring the roles of 5-HT2A and 2C receptors in neural crest-derived tissue differentiation and embryological development. Using Xenopus laevis embryos as a model, the study examined the effects of 5-HT2A agonists and 2C antagonists on morphogenesis. Findings indicated receptor-specific alterations in cranial and ocular morphogenesis, highlighting potential implications for human fetal development. These insights suggest caution for pregnant individuals using serotonergic agents, due to possible permanent changes in neural crest derivatives. This underscores the need for further research on serotonin receptors in embryological contexts.

Keywords

5-HT2A receptors

neural crest

Xenopus laevis

embryological development

serotonergic agents