AOA-OMED Research Posters 2024-OMED24-POSTERS

Video Transcription

Video Summary

This research, led by Julie Oakes at NYIT-COM, explores the effects of warfarin, a common anticoagulant, on vascular calcification using DBA2J mice as models. The study observed that 10 weeks post-warfarin discontinuation, calcification persisted, unaffected by sex. Warfarin usage correlated with increased aortic calcification and changes in left ventricular mass, though ejection fraction and cardiac output remained stable. The research indicates potential long-term cardiovascular impacts for warfarin users, independent of sex, and highlights further investigation into physiological compensatory responses, such as aortic root dilatation. The project received support from NYIT-COM Academic Medicine Scholars Program.

Keywords

warfarin

vascular calcification

DBA2J mice

cardiovascular impacts

NYIT-COM